University of Missouri Extension specialists urge producers to closely watch cattle grazing pastures with Johnson grass and other sorghum species.

Cattle producers in several drought-stressed parts of Missouri have recently reported cattle deaths from suspected prussic acid or hydrocyanic acid (cyanide) poisoning, says Tim Evans, an MU Extension state specialist in animal health and veterinary toxicology.

Prussic acid poisoning results when cattle eat cyanide-producing compounds in immature leaves of sorghum grasses or leaves of cherry and related species of fruit trees. This happens most often after extreme weather conditions such as drought or frost.

Evans says more than 70 adult cattle in southwestern Missouri died shortly after being released into drought-stressed pasture with lush new growth of Johnson grass.

Within a few hours of grazing in this pasture, several cows suddenly lay down and died or staggered briefly before collapsing and dying, says Evans. Few other clinical signs were observed. The remaining cattle were returned to the pasture, after which several more animals died.

Necropsies of 10 of the dead animals showed varying degrees of bright, cherry red blood. Evans says this is commonly observed in prussic acid poisoning because cyanide inhibits aerobic metabolism and prevents oxygen in the blood from being released to the tissues.

Samples from the necropsied animals were preserved for further testing. So far, Evans and diagnosticians from MU’s College of Veterinary Medicine have preliminarily ruled out carbohydrate overload, grass tetany, nitrate/nitrite intoxication, anaplasmosis and toxins from harmful algal blooms.

Though it can be challenging to accurately measure the presence of cyanide in postmortem samples, prussic acid poisoning remains the most likely cause of death, Evans says.

Sorghum forages include sorghum-Sudan hybrids, forage sorghum, Sudan grass and Johnson grass. These forages can accumulate nitrate in their stems – especially in response to drought – and cyanide-producing compounds in their leaves, particularly in rapidly growing immature plants.

Prussic acid poisoning from these annual forages happens most often when abundant rainfall interrupts or immediately follows a drought.

“When there’s a drought, these warm-season annuals quit growing but still take up nitrogen from the soil and accumulate nitrates and cyanide-producing compounds,” says MU Extension State Forage Specialist Craig Roberts. When rain comes, drought-stunted plants can start to look green and lush, and rapid new growth can occur.

Roberts and Evans agree that there is general awareness of concerns about grazing these forages immediately after frost, but they say producers might not know that what looks like excellent green grass for grazing might have high concentrations of cyanide-producing compounds following rainfall during or after drought.

Consult your veterinarian immediately if cattle collapse suddenly, die or exhibit labored breathing and staggering after being introduced to stunted or immature sorghum grasses, says Evans. Veterinarians can administer intravenous sodium nitrite and sodium thiosulfate to treat prussic acid poisoning, but animals frequently die before treatment begins.

Prevention is likely the best way to address concerns about sorghum-related prussic acid poisoning:

Evans discusses prussic acid intoxication and other drought-related intoxications in three videos: