USDA has approved Titanium 5 + PH-M, a new Elanco vaccine that protects cattle against the viruses and bacteria most associated with Bovine Respiratory Disease (BRD).
The U.S. Department of Agriculture (USDA) has issued a Veterinary Biologics License for Titanium® 5 + PH-M, a new vaccine that protects cattle against the viruses and bacteria most associated with bovine respiratory disease (BRD).
The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Do not vaccinate within 21 days of slaughter.
Elanco, Master Guard®, Titanium®, Viralign and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.
*Titanium 5 + PH-M may be administered to pregnant cattle provided they were vaccinated, according to label directions, with Titanium 3, Titanium 4 L5, Titanium 5, Titanium 5 L5 HB or Titanium 5 + PH-M 30 to 60 days prior to breeding.
**Titanium 5 + PH-M may also be administered to calves nursing pregnant cows provided their dams were vaccinated as described above.
1Efficacy study for BRSV fraction to demonstrate compatibility of the BRSV component in APHIS product code: 45B9.20 (unlicensed). Study No. 2011-05 Rev. 1.
2Terhaar, B. Interleukin-2 receptor response to Titanium 5 L5. Study No. TR-08. Published by Agri Laboratories Ltd.
3Demonstration of the compatibility of components between APHIS product codes 1181.20 (Establishment 213) and G935.04 (Establishment 315) APHIS product code 45B9.20. Study No. 2010-01 Rev. 1.
4Titanium and Master Guard vaccines: Flexibility for preconditioning. Published by Agri Laboratories Ltd.
5Terhaar, B. 1999. A comparison of Titanium 5 L5 and Bovishield 4 L5 following virulent infectious bovine rhinotracheitis virus challenge. Study No. TR-04. Published by Agri Laboratories Ltd.
6Post-vaccinal body temperature response in cattle. Agri Laboratories Ltd.
7Ohnesorge, W. C. 1998. Immunogenicity of a modified live bovine viral diarrhea virus, type 1 and type 2, vaccine following BVDV 890 (type 2) challenge. Study No. 97-24.
8Immune response of calves to MLV and killed vaccines at branding and weaning — in the face of maternal antibodies. Study No. TR-20. Published by Agri Laboratories Ltd.
9Endsley, J. J., M. J. Quade, B. Terhaar, and J. A. Roth. 2002. Bovine viral diarrhea virus type 1- and type 2-specific bovine T lymphocyte-subset responses following modified-live virus vaccination. Vet. Ther. 3(4):364-372.
10Milliken, G. A. 2013. Mannheimia haemolytica efficacy studies demonstrating the absence of excessive interference of Titanium products with the Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid.
11Porter, M. 2011. Field safety evaluation of bovine rhinotracheitis-virus diarrhea-parainfluenza3-respiratory syncytial virus vaccine, modified live virus, APHIS product code 1181.20 (establishment 213) in combination with Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid, APHIS product code: G935.04 (establishment 315). Protocol No. 2011-01, Rev. 02.
12Field safety evaluation in pregnant cows. Study No. 02-11 Rev. No. 1. Published by Agri Laboratories Ltd.
13Terhaar, B. 2001. Evaluating the effects of vaccine-induced stress on productivity. Study No. TR-13. Published by Agri Laboratories Ltd.
14Terhaar, B. Effect of vaccination with Titanium 5. Study No. TR-11. Published by Agri Laboratories Ltd.
15Terhaar, B. 2000. Effect of vaccination with Titanium 5 on milk production in dairy cattle. Study No. TR-09. Published by Agri Laboratories Ltd.
16Terhaar, B. 1998. Final report on field safety evaluation of Titanium 5 L5. Study No. TR-03. Published by Agri Laboratories Ltd.
17Edwards, A. J. 1996. Respiratory Diseases of Feedlot Cattle in the Central USA. Bovine Practitioner. 30:5-7.
18Galyean, M. L., L. J. Perino and G. C. Duff. 1999. Interaction of Cattle Health/Immunity and Nutrition. J. Anim. Sci. 77:1120-1134.
19Loneragan, G. H., D. A. Dargatz, P. S. Morley, and M. A. Smith. 2001. Trends in Mortality Ratios Among Cattle in US Feedlots. J. Am. Vet. Med. Assoc. 219:1122-1127.
20Chirase, N. K. and L. W. Greene. 2001. Dietary zinc and manganese sources administered from the fetal stage onwards affect immune response of transit stressed and virus infected offspring steer calves. Animal Feed Science and Technology. 93:217-228.
21Wittum T. E., N. E. Woollen, L. J. Perino and E. T. Littledike. 1996. Relationships among treatment for respiratory tract disease, pulmonary lesions evident at slaughter, and rate of weight gain in feedlot cattle. J. Am. Vet. Med. Assoc. Aug 15;209(4):814-8.