INTERVET/SCHERING-PLOUGH ANIMAL HEALTH EXPANDS VETERINARY VACCINE MANUFACTURING FACILITY AT BIOSCIENCES CENTER BOXMEER

Boxmeer (the Netherlands), November 9, 2010 – Today, Intervet/Schering-Plough Animal

Health announced that it has opened a specialized filling and freeze-drying unit for

veterinary vaccines at its Biosciences Center Boxmeer in the Netherlands. The opening

of the Central Filling and Freeze-drying Department was performed by her Royal

Highness Princess Máxima of the Netherlands in the presence of His Excellency the

Minister of Economic Affairs, Agriculture and Innovation, Maxime Verhagen, and other

guests.

The extension of the Central Filling and Freeze-drying Department, of which the construction

started in September 2008 at a total investment of US$ 18 Million (€ 13 Million), has been

designed to meet the latest requirements related to Good Manufacturing Practices (GMP) and

Safety, Health and Environment (SHE) and brings all freeze-dried vaccine activities at

Biosciences Center Boxmeer together in one building. In the state-of-the-art facility, the latest

technology has been implemented, e.g. rapid transfer port technology to connect the filling line

to the vaccine bulk tank as well as fully automated systems for the loading of the freeze-dryer.

“With this significant investment into the new unit here in Boxmeer we ensure the high

standards and efficient manufacturing process at this important facility in our manufacturing

network and enable the people that work here to continue contributing to the success of our

growing vaccine business”, says Malte Greune, Senior Vice-President Animal Health

Manufacturing.

Helmut Finkler, Chairman Animal Health Operations The Netherlands adds: “The extension of

the Central Filling and Freeze-drying Department allows to further leverage the existing knowhow

and expertise at the Biosciences Center Boxmeer and is another element on our journey

“Fit for the Future” as a leading Biotech site within our industry. It also underlines the long-term

commitment of the company to this location.”

The new filling line has a maximum speed of 24,000 glass vials per hour and the freeze-dryer

can process 136,000 vials per batch. The Central Filling and Freeze-drying Department

employs approximately 65 people and produces primarily freeze-dried vaccines for companion

animals (dogs, cats), cattle, swine, horses and poultry. The new unit has been certified last July

and vaccine production of market batches started in September 2010.

To address the specific regional needs for veterinary medicines, Intervet/Schering-Plough

Animal Health operates 28 manufacturing sites in 14 countries distributed over 5 continents. Of

these, Biosciences Center Boxmeer is a global lead site which produces vaccines and

pharmaceutical products against bacterial, parasitological, and viral infections in cattle, sheep,

swine, poultry, fish and companion animals. The company markets more than 350 licensed

vaccines of which more than 100 are manufactured in Boxmeer. The company continuously

invests in its operations to accommodate growth and to ensure that it meets GMP and other

standards as well as the most stringent environmental requirements.

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