Cofactor Genomics Develops World’s First Bos taurus Exome Capture Product

Cofactor Genomics, a leading biotechnology company, announced today it will release a product to allow researchers to selectively enrich, sequence, analyze and detect variants in coding and regulatory regions of the Bovine (cow) genome. This will permit researchers to investigate and discover variation across any breed of beef and dairy cattle and will accelerate the pace of scientific research and discoveries for one of the world’s largest food sources.

Cofactor Genomics collaborated with members of the Bos Taurus community and the USDA Agricultural Research Service, who provided mRNA and EST data, to design probes to capture the most comprehensive set of coding and regulatory regions possible. Cofactor utilized the Bos Taurus assembly from the Center for Bioinformatics and Computational Biology at University of Maryland, called UMD3.1, as the foundation for the development of their in-solution capture product.

The exome capture strategy will allow researchers to selectively pull-down and sequence approximately 46 Mb of the cow genome for hypothesis-neutral marker and haplotype analysis as well as study and selectively breed for disease resistance, carcass quality, and palatability. Cofactor is capable of providing hybridization, library generation, sequencing, analysis, and visualization services for all samples and will begin accepting orders in early December, 2011. Current research methods leverage technologies that require prior knowledge of genomic variation.

These methods include genotyping arrays consisting of SNP’s gathered from Bovine HapMap and other sources and small-scale PCR to assess variation in a small number of genomic regions. In contrast, Cofactor’s product will provide sequence-verified SNP’s, insertions, and deletions, without any prior knowledge of genomic variation, at single-base resolution. Dr. Jarret Glasscock, CEO and founder of Cofactor Genomics, commented, "The development of an in-solution whole-exome capture strategy for Bos Taurus will further allow agricultural researchers to investigate and discover causative variation in cattle, at unparalleled resolution. This product will also allow researchers to probe the regulatory and coding regions of the cow genome without spending money to sequence repetitive areas. Cofactor is excited to lead the way in this agricultural genomics revolution through our Bench To Barnyard™ products and services.”

About Cofactor Genomics, LLC

Cofactor Genomics is a privately held biotechnology company that employs experimental design, next-generation sequencing, and proprietary analysis technology and pipelines to drive the discovery and design of new products and processes for the life sciences field. Cofactor’s D&A (Design & Analysis) Solution is constructed to specifically assist those researchers who require more than just sequencing at a reasonable cost. It also provides expert design and analysis capabilities, customized to specific requirements, and bioinformatics to make the most of the data that is generated. Cofactor’s expertise in molecular biology and bioinformatics accelerates its partners’ biological research, discovery and product development in a number of scientific areas worldwide. For more information, visitwww.cofactorgenomics.com.

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